Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia-Reference-Cited by-同舟云学术

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia

Published:2023-03-01 Issue:3 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Palicharla Vivek Reddy¹,Hwang Sun-Hee¹,Somatilaka Bandarigoda N.¹,Legué Emilie²,Shimada Issei S.¹,Familiari Nicole E.¹,Tran Vanna M.¹,Woodruff Jeffrey B.¹,Liem Karel F.²,Mukhopadhyay Saikat¹

Affiliation:

1. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390

2. Vertebrate Developmental Biology Program, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520

Abstract

Mechanisms of ciliary transport of ARL13B, a common ciliary protein, by TULP3 are described. An amphipathic helix preceding the ARL13B GTPase domain that couples with the TULP3 tubby domain for ciliary transport is identified. These findings implicate the tubby domain in capturing helical secondary structural motifs from cargoes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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