Electric field–guided collective motility initiation of large epidermal cell groups-Reference-Cited by-同舟云学术

Electric field–guided collective motility initiation of large epidermal cell groups

Published:2023-05-01 Issue:5 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Sun Yaohui¹²,Reid Brian¹,Zhang Yan¹,Zhu Kan¹,Ferreira Fernando¹³^ORCID,Estrada Alejandro¹,Sun Yuxin¹,Draper Bruce W.⁴,Yue Haicen⁵,Copos Calina⁶,Lin Francis⁷,Bernadskaya YelenaY.²,Zhao Min¹,Mogilner Alex²^ORCID

Affiliation:

1. Department of Ophthalmology and Vision Science and Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817

2. Courant Institute and Department of Biology, New York University, New York, NY 10012

3. Departamento de Biologia, Centro de Biologia Molecular e Ambiental (CBMA), Universidade do Minho, 4710-057 Braga, Portugal

4. Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616

5. Department of Physics, Emory University, Atlanta, GA 30322

6. Department of Biology and Department of Mathematics, Northeastern University, Boston, MA 02115

7. Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

Abstract

Large zebrafish keratocyte groups initiate motility in response to a physiological electric field. The groups move towards the cathode, with greatest cell velocity at the group front. Inhibiting PI3K does not affect the cathode-directed group migration, but cells at the group rear have the greatest velocity. Myosin inhibition disrupts group cohesion and directional switching. Our results suggest that individual cells sense the electric field, and mechanical integration enables group movement.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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1. Observations on the social behaviour of cells in tissue culture

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3. Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials

4. Balance between cell−substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes

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