MARVEL domain containing CMTM4 affects CXCR4 trafficking-Reference-Cited by-同舟云学术

MARVEL domain containing CMTM4 affects CXCR4 trafficking

Published:2022-11-01 Issue:13 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bona Alexandra¹²,Seifert Michael¹,Thünauer Roland³⁴,Zodel Kyra⁵,Frew Ian J.⁵⁶⁷,Römer Winfried⁷⁸⁹,Walz Gerd¹⁷,Yakulov Toma A.¹^ORCID

Affiliation:

1. Renal Division and

2. Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany

3. Technology Platform Light Microscopy and Image Analysis (TP MIA), Leibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany

4. Advanced Light and Fluorescence Microscopy (ALFM) Facility, Centre for Structural Systems Biology (CSSB), 22607 Hamburg, Germany

5. Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany

6. German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

7. Signalling Research Centres BIOSS and CIBSS

8. Freiburg Institute for Advanced Studies (FRIAS), and

9. Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany

Abstract

Defective zebrafish cmtm4 slowed the development of the posterior lateral line (pLL) by altering the Cxcr4b gradient across the pLL primordium (pLLP). Analysis in mammalian cells uncovered that CMTM4 interacted with CXCR4 and altered its glycosylation pattern but did not affect internalization or degradation of CXCR4.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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