CLASP2 facilitates dynamic actin filament organization along the microtubule lattice-Reference-Cited by-同舟云学术

CLASP2 facilitates dynamic actin filament organization along the microtubule lattice

Published:2023-03-01 Issue:3 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Rodgers N. C.¹,Lawrence E. J.²,Sawant A. V.²,Efimova N.²,Gonzalez-Vasquez G.³,Hickman T. T.⁴,Kaverina I.²,Zanic M.²⁵⁶^ORCID

Affiliation:

1. Chemical and Physical Biology Graduate Program, Vanderbilt University, Nashville, TN 37232

2. Department of Cell and Development Biology, Vanderbilt University, Nashville, TN 37232

3. Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN 37232

4. Quantitative and Chemical Biology Graduate Program, Vanderbilt University, Nashville, TN 37232

5. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37232

6. Department of Biochemistry, Vanderbilt University, Nashville, TN 37232

Abstract

CLASP2α directly cross-links multiple actin filaments to the microtubule lattice. CLASP2α-mediated cross-linking facilitates dynamic organization of actin filaments templated by microtubules. Furthermore, CLASP depletion results in disorganized actin fibers and reduced coalignment of actin fibers with microtubules, suggesting that microtubule–CLASP–actin interaction may influence overall cytoskeletal organization in cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference53 articles.

1. CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain

2. CLASPs Are CLIP-115 and -170 Associating Proteins Involved in the Regional Regulation of Microtubule Dynamics in Motile Fibroblasts

3. CLASP Promotes Microtubule Rescue by Recruiting Tubulin Dimers to the Microtubule

4. Interactions between the Microtubule Binding Protein EB1 and F-Actin

5. Arrangement of Subunits in Flagellar Microtubules

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