PI3P regulates multiple stages of membrane fusion-Reference-Cited by-同舟云学术

PI3P regulates multiple stages of membrane fusion

Published:2023-03-01 Issue:3 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Orr Amy¹,Wickner William¹

Affiliation:

1. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755-3844

Abstract

Using reconstituted fusion with all purified proteins and defined lipids, four targets for PI3P regulation are reported: recruitment of the Qc-SNARE, trans-SNARE assembly between membranes, protection of SNARE complexes from the chaperones Sec17 and Sec18 by the conserved tethering complex HOPS, and fusion per se after tethering.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference56 articles.

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4. Stimulation of NSF ATPase Activity by α-SNAP Is Required for SNARE Complex Disassembly and Exocytosis

5. A cycle of Vam7p release from and PtdIns 3-P–dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion

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3. Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE;Molecular Biology of the Cell;2023-08-01