Affiliation:
1. Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY 13210
Abstract
The role of the focal adhesion adaptor paxillin in regulating the Rab5 GTPase is evaluated. Paxillin, through modulation of HDAC6 activity and thereby microtubule acetylation, was shown to regulate Rab5 activity, as well as Rab5-associated vesicle distribution and motility.
Publisher
American Society for Cell Biology (ASCB)
Subject
Cell Biology,Molecular Biology