Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments-Reference-Cited by-同舟云学术

Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments

Published:2022-07-01 Issue:8 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yang Ai-Wen¹,Lin Ni-Hsuan¹,Yeh Ting-Hung²,Snider Natasha³,Perng Ming-Der¹²

Affiliation:

1. Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan

2. Department of Medical Science, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan

3. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Abstract

The effects of the GFAP rod end mutations are dominant, changing the assembly process in a way that promotes GFAP aggregation and decreases GFAP solubility. Using Alexander disease brain tissues, clinically relevant evidence is provided that links GFAP assembly defects to disease pathology at the tissue level.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference69 articles.

1. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

2. Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages

3. Helix geometry in proteins

4. Alexander disease with serial MRS and a new mutation in the glial fibrillary acidic protein gene

5. Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins;2024-09-05

2. Intermediate filaments at a glance;Journal of Cell Science;2024-08-15

3. Glial fibrillary acidic protein is pathologically modified in Alexander disease;Journal of Biological Chemistry;2024-07

4. Vimentin filaments integrate low-complexity domains in a complex helical structure;Nature Structural & Molecular Biology;2024-04-17

5. The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats;Naunyn-Schmiedeberg's Archives of Pharmacology;2023-12-15