Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes-Reference-Cited by-同舟云学术

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes

Published:2023-08-01 Issue:9 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Maruzs Tamás¹,Feil-Börcsök Dalma¹²,Lakatos Enikő¹²,Juhász Gábor¹,Blastyák András¹,Hargitai Dávid³,Jean Steve⁴^ORCID,Lőrincz Péter³,Juhász Gábor¹³

Affiliation:

1. Institute of Genetics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, H-6726 Hungary

2. Doctoral School of Biology, University of Szeged, Szeged, H-6726 Hungary

3. Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, H-1117 Hungary

4. Department of Anatomy and Cell Biology, University of Sherbrooke, Sherbrooke, J1E 4K8 Canada

Abstract

We report a novel function of the sorting nexin 25 homolog Snazarus in larval garland nephrocytes, the highly endocytic, podocyte-like cells of Drosophila. We propose a model in which Snz negatively regulates exocytosis via its interaction with Rab11, thus contributing to the maintenance of membrane balance in the endosomal system of nephrocytes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference53 articles.

1. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction

2. SNX-PXA-RGS-PXC Subfamily of SNXs in the Regulation of Receptor-Mediated Signaling and Membrane Trafficking

3. Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes

4. Five common gene variants identify elevated genetic risk for coronary heart disease

5. Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis

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