Dynamic glucose uptake, storage, and release by human microvascular endothelial cells-Reference-Cited by-同舟云学术

Dynamic glucose uptake, storage, and release by human microvascular endothelial cells

Published:2022-10-01 Issue:12 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yazdani Samaneh¹,Bilan Philip J.¹,Jaldin-Fincati Javier R.¹,Pang Janice¹,Ceban Felicia¹,Saran Ekambir¹,Brumell John H.¹²³⁴,Freeman Spencer A.¹⁵,Klip Amira¹⁵⁶⁷

Affiliation:

1. Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4

2. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada, M5S 1A1

3. Institute of Medical Science, University of Toronto, Toronto, ON, Canada, M5S 1A1

4. SickKids IBD Centre, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4

5. Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A1

6. Department of Paediatrics, University of Toronto, Toronto, ON, Canada, M5S 1A1

7. Department of Physiology, University of Toronto, Toronto, ON, Canada, M5S 1A1

Abstract

We followed radioactive and fluorescent glucose derivatives in human microvascular endothelial cells (HAMEC). [3H]-2-DG entered via GLUT1/3 and 20% incorporated into glycogen. Glycogenolysis and 2-DG-6-phosphate provided glucose that exited cells via GLUT3. 2-NBDG revealed a parallel endocytic process evincing complex glucose handling by HAMEC.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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