Arf5-mediated regulation of mTORC1 at the plasma membrane

Abstract

Arf5 is identified as a novel interaction partner with the mTORC1 subunit, Raptor, and a regulator of mTORC1 signaling at PM ruffles. The findings reveal a Arf5-dependent pathway for recruitment and activation of mTORC1 at PM ruffles, a process relevant for spatial and temporal regulation of mTORC1 by receptor and nutrient stimuli.