MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles-Reference-Cited by-同舟云学术

MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles

Published:2023-01-01 Issue:1 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Laguillo-Diego Alejandra¹^ORCID,Kiewisz Robert²^ORCID,Martí-Gómez Carlos³^ORCID,Baum Daniel⁴,Müller-Reichert Thomas²^ORCID,Vernos Isabelle¹⁵⁶^ORCID

Affiliation:

1. Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona 08003, Spain

2. Experimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany

3. Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

4. Department of Visual and Data-Centric Computing, Zuse Institute Berlin, 14195 Berlin, Germany

5. Universitat Pompeu Fabra, Barcelona 08003, Spain

6. ICREA, Barcelona 08010, Spain

Abstract

Microtubule (MT) minus ends in HeLa cell metaphase spindles have open or closed morphologies in electron tomograms. The proportion of open MT minus ends increases upon silencing the minus end–specific stabilizer, MCRS1, suggesting a correlation between their morphology and dynamic state. This points to an unsynchronized behavior of MTs at the spindle poles.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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