Chaperone requirements for de novo folding of Saccharomyces cerevisiae septins

Abstract

Septin proteins evolved from GTPases and form cytoskeletal filaments. Other cytoskeletal NTPases (actin and tubulins) require molecular chaperones to fold. Many chaperones bind septins, but functional requirements were unknown. A combination of in vivo and in vitro analyses found roles for specific chaperones in efficient folding of yeast septins.