Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation-Reference-Cited by-同舟云学术

Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation

Published:2022-11-01 Issue:13 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Cason Sydney E.¹^ORCID,Mogre Saurabh S.²^ORCID,Holzbaur Erika L. F.¹^ORCID,Koslover Elena F.²^ORCID

Affiliation:

1. Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104

2. Department of Physics, University of California, San Diego, La Jolla, CA 92093

Abstract

Autophagosome-lysosome fusion is required to clear cellular waste and maintain neuronal homeostasis. Computational modeling and microscopy elucidate the dynamics of autophagosome-lysosome interaction in axons. Each autophagosome fuses with only a few lysosomes, and autophagosomal maturation is limited by slow kinetics of inner membrane breakdown.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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