The <i>Tetrahymena bcd1</i> mutant implicates endosome trafficking in ciliate, cortical pattern formation-Reference-Cited by-同舟云学术

The Tetrahymena bcd1 mutant implicates endosome trafficking in ciliate, cortical pattern formation

Published:2023-07-01 Issue:8 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Cole Eric S.¹^ORCID,Maier Wolfgang²,Joachimiak Ewa³,Jiang Yu-yang⁴,Lee Chinkyu⁵,Collet Erik⁶,Chmelik Carl¹^ORCID,Romero Daniel P.⁷,Chalker Douglas⁸,Alli Nurudeen K.⁸,Ruedlin Tina M.⁸,Ozzello Courtney⁹,Gaertig Jacek⁵

Affiliation:

1. Biology Department, St. Olaf College, Northfield, MN 55057

2. Bioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg, Germany

3. Laboratory of Cytoskeleton and Cilia Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland

4. Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637

5. Department of Cellular Biology, University of Georgia, Athens, GA 30605

6. Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

7. Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455

8. Department of Biology, Washington University in St. Louis, St. Louis, MO 63021

9. Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309

Abstract

In the ciliate Tetrahymena thermophila, the BCD1 pattern-gene encodes a Beige-BEACH-domain protein that defines cortical organelle dimensions through regulated endocytic activity. Tetrahymena cells homozygous for a bcd1 loss-of-function mutation exhibit supernumerary cortical organelles including oral apparatuses, cytoprocts and contractile vacuole pores. Elements of the broadened cortical domain phenotype can be phenocopied by disrupting clathrin-mediated endocytosis, suggesting that exocytic membrane delivery is balanced by endocytic retrieval of cortical pattern determinants..

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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