p115RhoGEF activates RhoA to support tight junction maintenance and remodeling-Reference-Cited by-同舟云学术

p115RhoGEF activates RhoA to support tight junction maintenance and remodeling

Published:2022-12-01 Issue:14 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Chumki Shahana A.¹^ORCID,van den Goor Lotte M.²^ORCID,Hall Benjamin N.²,Miller Ann L.¹²^ORCID

Affiliation:

1. Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109

2. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109

Abstract

This study investigates which RhoGEF locally activates RhoA at sites of local tight junction loss. We find that p115RhoGEF activates Rho flares during local tight junction remodeling and plays a critical role in maintaining junctional RhoA to support apical actomyosin and cell-cell junctions to preserve epithelial barrier function.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference49 articles.

1. A Mechanosensitive RhoA Pathway that Protects Epithelia against Acute Tensile Stress

2. Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

3. Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function

4. Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

5. Concentric zones of active RhoA and Cdc42 around single cell wounds

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