BAG6 supports stress fiber formation by preventing the ubiquitin-mediated degradation of RhoA

Abstract

We identified BAG6 as the first factor need to protect RhoA from ubiquitination. BAG6 deficiency enhanced the association between Cullin-3 (CUL3) and RhoA, promoted its polyubiquitination, and stimulated the degradation of RhoA, leading to the abrogation of F-actin polymerization. These findings reveal a crucial role for BAG6 in stress fiber formations.