Roles for a lipid phosphatase in the activation of its opposing lipid kinase-Reference-Cited by-同舟云学术

Roles for a lipid phosphatase in the activation of its opposing lipid kinase

Published:2020-08-01 Issue:17 Volume:31 Page:1835-1845
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Strunk Bethany S.¹²³^ORCID,Steinfeld Noah¹⁴,Lee Sora⁵,Jin Natsuko¹,Muñoz-Rivera Cecilia³,Meeks Garrison³,Thomas Asha³,Akemann Camille¹,Mapp Anna K.¹,MacGurn Jason A.⁵,Weisman Lois S.¹²⁴^ORCID

Affiliation:

1. Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109

2. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109

3. Department of Biology, Trinity University, San Antonio, TX 78212

4. Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109

5. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232

Abstract

The phosphoinositide phosphatase Fig4 is predicted to turn over the signaling lipid PI3,5P2. It is shown that a major role of Fig4 is to elevate PI3,5P2 via dynamic regulation of the protein complex that activates its opposing lipid kinase, Fab1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference54 articles.

1. A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

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4. Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2

5. FIG4 regulates lysosome membrane homeostasis independent of phosphatase function

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