Exploiting DNA repair defects for novel cancer therapies-Reference-Cited by-同舟云学术

Exploiting DNA repair defects for novel cancer therapies

Published:2016-07-15 Issue:14 Volume:27 Page:2145-2148
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

van Gent Dik C.¹,Kanaar Roland¹²

Affiliation:

1. Department of Molecular Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015, Netherlands

2. Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam 3015, Netherlands

Abstract

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck—patient selection—can be approached.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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2. Engineered In Vitro Disease Models

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5. DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

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