The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions-Reference-Cited by-同舟云学术

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions

Published:2020-11-01 Issue:23 Volume:31 Page:2522-2536
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Owen Izzy¹,Rhoads Shannon¹,Yee Debra¹,Wyne Hala¹,Gery Kevin¹,Hannula Isabelle¹,Sundrum Meenakshi¹,Shewmaker Frank¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814

Abstract

We characterized novel phosphorylation patterns in FUS’s prion-like domain when FUS was cytoplasmic due to disease mutation or cellular stress. Phosphomimetic substitutions at kinase sites suggest moderate phosphorylation of FUS’s prion-like domain can profoundly disrupt solid-phase transitions with little effect on liquid-phase transitions.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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