Modeling and analysis of the macronutrient signaling network in budding yeast-Reference-Cited by-同舟云学术

Modeling and analysis of the macronutrient signaling network in budding yeast

Published:2021-11-01 Issue:21 Volume:32 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Jalihal Amogh P.¹,Kraikivski Pavel²,Murali T. M.³,Tyson John J.²⁴

Affiliation:

1. Genetics, Bioinformatics, and Computational Biology PhD Program

2. Division of Systems Biology, Academy of Integrated Science, Virginia Tech, Blacksburg, VA 24061

3. Department of Computer Science, Virginia Tech, Blacksburg, VA 24061

4. Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061

Abstract

A computational model of the underlying regulatory mechanisms is proposed to study nutrient signaling. The model’s predictions are consistent with literature-curated experimental measurements. Using this model, novel, testable predictions are made in genetic mutant strains undergoing complex nutrient shifts.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference48 articles.

1. Protein Kinase A Contributes to the Negative Control of Snf1 Protein Kinase in Saccharomyces cerevisiae

2. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

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4. The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein

5. Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

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