Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration-Reference-Cited by-同舟云学术

Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration

Published:2021-04-01 Issue:7 Volume:32 Page:590-604
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Zong Hailing¹,Hazelbaker Mark²,Moe Christina¹,Ems-McClung Stephanie C.²,Hu Ke¹,Walczak Claire E.²

Affiliation:

1. Department of Biology, Indiana University, Bloomington, IN 47405

2. Medical Sciences, Indiana University School of Medicine–Bloomington, Bloomington, IN 47405

Abstract

MCAK activity is spatially regulated in migrating cells in which its activity is lower at the leading edge than the trailing edge. Global inhibition of MCAK disrupts this spatial regulation and causes defects in centrosome re-orientation and focal adhesion turnover that reduces cell polarization needed for robust directed migration.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference77 articles.

1. Microtubules and actin crosstalk in cell migration and division

2. Aurora B Regulates MCAK at the Mitotic Centromere

3. Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

4. Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

5. Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells

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