Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization-Reference-Cited by-同舟云学术

Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

Published:2021-02-01 Issue:3 Volume:32 Page:247-259
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Langness Vanessa F.¹²,van der Kant Rik³⁴,Das Utpal⁵²,Wang Louie¹²,Chaves Rodrigo dos Santos¹²,Goldstein Lawrence S. B.¹⁵²

Affiliation:

1. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093

2. Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037

3. Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands

4. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands

5. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093

Abstract

Statins reduce Aβ production by decreasing BACE1 interaction with amyloid precursor protein (APP) and enhancing APP dimerization. It is suggested that this process is regulated through competition between APP dimerization and APP cholesterol binding.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference66 articles.

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4. Structural features of the KPI domain control APP dimerization, trafficking, and processing

5. Palmitoylated APP Forms Dimers, Cleaved by BACE1

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