R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast-Reference-Cited by-同舟云学术

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

Published:2021-01-01 Issue:1 Volume:32 Page:74-89
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Mishra Prashant K.¹,Chakraborty Arijita²,Yeh Elaine³,Feng Wenyi²,Bloom Kerry S.³,Basrai Munira A.¹

Affiliation:

1. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

2. SUNY Upstate Medical University, Syracuse, NY 13210

3. Department of Biology, University of North Carolina, Chapel Hill, NC 27599

Abstract

This study from budding yeast provides mechanistic insights into how accumulation of R-loops at centromeric chromatin perturbs kinetochore integrity and contributes to chromosome instability.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference83 articles.

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4. Altered Dosage and Mislocalization of Histone H3 and Cse4p Lead to Chromosome Loss in Saccharomyces cerevisiae

5. Chromosomal Instability, Aneuploidy, and Cancer

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