Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10-Reference-Cited by-同舟云学术

Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10

Published:2021-01-01 Issue:1 Volume:32 Page:57-73
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Brumfield Alexandria¹,Chaudhary Natasha¹,Molle Dorothee¹,Wen Jennifer¹,Graumann Johannes²,McGraw Timothy E.¹³

Affiliation:

1. Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065

2. Weill Cornell Medical College in Qatar, Education City, 24144 Doha, State of Qatar

3. Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10065

Abstract

Insulin signaling mobilizes glucose transporter 4 (GLUT4) from the trans-Golgi network (TGN) through the AKT-TBC1D4-RAB10 signaling module. GLUT4 localizes to a region of the TGN responsible for retention and release of ATP7A copper transporter and the sorting of lysosomal enzymes to late endosomes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference69 articles.

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