Novel cytokinetic ring components drive negative feedback in cortical contractility-Reference-Cited by-同舟云学术

Novel cytokinetic ring components drive negative feedback in cortical contractility

Published:2020-07-15 Issue:15 Volume:31 Page:1623-1636
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bell Kathryn Rehain¹²,Werner Michael E.¹,Doshi Anusha¹,Cortes Daniel B.¹,Sattler Adam¹,Vuong-Brender Thanh³,Labouesse Michel³,Maddox Amy Shaub¹²

Affiliation:

1. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

2. Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

3. Institut de Biologie Paris-Seine, Sorbonne Université, INSERM, 75005 Paris, France

Abstract

Novel cytokinetic ring proteins, the Ste20 family kinase GCK-1 (germinal center kinase-1) and its heterodimeric cofactor CCM-3 (cerebral cavernous malformations-3), close a negative feedback loop involving the RhoA GAP RGA-3/4, RhoA, and its cytoskeletal effector anillin to limit actomyosin contractility in cytokinesis and during polarization of the Caenorhabditis elegans zygote.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference70 articles.

1. Spatiotemporal Regulation of RhoA during Cytokinesis

2. Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium

3. A cdk1 gradient guides surface contraction waves in oocytes

4. Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype

5. THE GENETICS OF CAENORHABDITIS ELEGANS

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