SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest

Author:

Caydasi Ayse Koca12,Khmelinskii Anton3,Darieva Zoulfia4,Kurtulmus Bahtiyar15,Knop Michael6,Pereira Gislene167

Affiliation:

1. Centre for Organismal Studies (COS), University of Heidelberg, Germany

2. Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey

3. Institute of Molecular Biology (IMB), Mainz, Germany

4. Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom

5. European Molecular Biology Laboratories (EMBL), Heidelberg, Germany

6. Centre for Molecular Biology (ZMBH), University of Heidelberg, Germany

7. German Cancer Research Centre (DKFZ), DKFZ-ZMBH Alliance, University of Heidelberg, Germany

Abstract

Caydasi et al. identified the SWR1 chromatin-remodeling complex (SWR1-C) among novel factors that are essential for the integrity of the spindle position checkpoint (SPOC). They show that cells lacking SWR1-C activate the SPOC upon spindle misorientation but undergo mitotic slippage due to the inability of holding a prolonged SPOC arrest.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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