Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites-Reference-Cited by-同舟云学术

Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites

Published:2020-10-01 Issue:21 Volume:31 Page:2398-2408
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Sharma Manisha¹,Wente Susan R.¹

Affiliation:

1. Department of Cell and Developmental Biology, School of Medicine, Vanderbilt University, Nashville, TN 37240

Abstract

We uncovered a nuclear role for human Gle1 in coordinating transcription termination. When nucleocytoplasmic shuttling of Gle1 is disrupted, nascent mRNA transcripts are elongated. Gle1 colocalizes with DDX1, and loss of Gle1 shuttling impairs recruitment of DDX1 to CstF-64 and transcription termination foci, leading to improper pre-mRNA cleavage.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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5. Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription

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