EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8-Reference-Cited by-同舟云学术

EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8

Published:2021-01-01 Issue:1 Volume:32 Page:1-14
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Tian Hui¹,Billings Timothy¹,Petkov Petko M.¹

Affiliation:

1. The Jackson Laboratory, Bar Harbor, ME 04609

Abstract

EWSR1, a protein whose role in meiosis was not previously clarified in detail, binds to both the recombination regulator PRDM9 and the phosphorylated meiosis-specific cohesin pREC8 in male meiotic cells and is essential for promoting PRDM9-dependent histone methylation and normal meiotic progress.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference80 articles.

1. High density of REC 8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation

2. A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

3. Variation in Genome-Wide Levels of Meiotic Recombination Is Established at the Onset of Prophase in Mammalian Males

4. Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots

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