The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80-Reference-Cited by-同舟云学术

The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80

Published:2021-04-15 Issue:8 Volume:32 Page:690-702
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Mashukova Anastasia¹²,Forteza Radia¹,Shah Viraj N.¹,Salas Pedro J.¹

Affiliation:

1. Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL 33136

2. Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314

Abstract

In addition to their function in apico-basal polarity, kinases such as MARK2 modulate innate immunity in epithelial cells. MARK2 phosphorylates 152Ser-Med17 downstream of aPKC modulating more than 100 genes, some of which are related to viral responses.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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