Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane-Reference-Cited by-同舟云学术

Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane

Published:2021-07-15 Issue:15 Volume:32 Page:1374-1392
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Kishimoto Takuma¹,Mioka Tetsuo¹,Itoh Eriko¹,Williams David E.²,Andersen Raymond J.²,Tanaka Kazuma¹

Affiliation:

1. Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Life Science, Sapporo, Hokkaido 060-0815, Japan

2. Departments of Chemistry and Earth, Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada

Abstract

Phospholipids are asymmetrically distributed in the plasma membrane (PM). However, our understanding of their physiological significance is still limited. Here we show that phospholipid flippases and a PM protein, Sfk1, cooperatively play an essential role in retaining ergosterol in the PM of budding yeast.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference21 articles.

1. Assess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayers

2. Thermodynamics of lipid interactions in complex bilayers

3. P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas

4. The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

5. Stt4 PI 4-Kinase Localizes to the Plasma Membrane and Functions in the Pkc1-Mediated MAP Kinase Cascade

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