Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2-Reference-Cited by-同舟云学术

Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2

Published:2021-02-01 Issue:3 Volume:32 Page:226-236
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Wayt Jessica¹,Cartagena-Rivera Alexander²,Dutta Dipannita³,Donaldson Julie G.¹,Waterman Clare M.¹

Affiliation:

1. Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda MD 20814

2. Section on Mechanobiology, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20814

3. National Center for Advancing Translational Sciences, Department of Health and Human Services, Rockville, MD 20850

Abstract

We utilize quantitative endocytic assays of endogenous clathrin-independent endocytosis (CIE) cargoes to determine that the Rho-associated kinase ROCK2, but not ROCK1, is required for CIE of major histocompatibility complex class I (MHCI) and CD59 through promotion of myosin II activity. We further show that myosin IIA promotes internalization of MHCI and myosin IIB drives CD59 uptake in both HeLa and polarized Caco2 cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference51 articles.

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