ALK1 regulates the internalization of endoglin and the type III TGF-β receptor-Reference-Cited by-同舟云学术

ALK1 regulates the internalization of endoglin and the type III TGF-β receptor

Published:2021-04-01 Issue:7 Volume:32 Page:605-621
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Tazat Keren¹,Pomeraniec-Abudy Leslie¹,Hector-Greene Melissa²,Szilágyi Szabina Szófia¹,Sharma Swati¹,Cai Elise M.²,Corona Armando L.²,Ehrlich Marcelo³,Blobe Gerard C.²,Henis Yoav I.¹

Affiliation:

1. Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel

2. Department of Medicine, Duke University Medical Center, Durham, NC 27708

3. Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel

Abstract

The relation between complex formation among TGF-β receptors and their endocytosis remained unclear. We show that the complexes formed regulate their endocytosis and signaling, with a major effect by ALK1. Our results link TGF-β receptor oligomerization and endocytosis based on which endocytosis signals are functional in specific receptor complexes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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