RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness-Reference-Cited by-同舟云学术

RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness

Published:2020-12-01 Issue:25 Volume:31 Page:2768-2778
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Colón-Bolea Paula¹,García-Gómez Rocío¹²,Shackleton Sue³,Crespo Piero¹²,Bustelo Xosé R.²⁴,Casar Berta¹²

Affiliation:

1. Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander 39011, Spain

2. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid 28029, Spain

3. Department of Biochemistry, University of Leicester, Leicester LE1 9HM, UK

4. Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (CSIC), Universidad de Salamanca, Salamanca 37007, Spain

Abstract

In our manuscript we show that GTPases RAC, RHO, and CDC42 were able to modify the nuclear morphology, especially Rac1 protein. Rac1 induces nuclear morphology alterations to enhance invasion of melanoma cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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