APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells-Reference-Cited by-同舟云学术

APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells

Published:2021-01-15 Issue:2 Volume:32 Page:120-130
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Faux Maree C.¹²,King Lauren E.¹²,Kane Serena R.¹²,Love Christopher¹²,Sieber Oliver M.¹²³⁴,Burgess Antony W.¹²⁴

Affiliation:

1. Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia

2. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia

3. Department of Biochemistry & Molecular Biology, Monash University, Clayton, Victoria 3800, Australia

4. Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3052, Australia

Abstract

Re-expression of wild-type APC promotes a p120-catenin isoform switch that restores an epithelial phenotype in colorectal cancer (CRC) cells. This switch is mediated by a change in Wnt-induced transcriptional control and an increase in the master epithelial regulator ESRP1. ESRP1 expression is down-regulated in primary CRCs with truncated APC.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference66 articles.

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5. Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

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