Mps1 promotes poleward chromosome movements in meiotic prometaphase-Reference-Cited by-同舟云学术

Mps1 promotes poleward chromosome movements in meiotic prometaphase

Published:2021-05-01 Issue:10 Volume:32 Page:1020-1032
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Meyer Régis E.¹,Tipton Aaron R.¹,LaVictoire Rebecca¹,Gorbsky Gary J.¹²,Dawson Dean S.¹²

Affiliation:

1. Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

2. Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

Abstract

Mps1 is a kinase that regulates several steps in mitosis and meiosis. Mps1 is essential for the spindle checkpoint and helps stabilize attachment of kinetochores to microtubules. Here we show that following microtubule attachment, Mps1 promotes microtubule depolymerization to trigger migration of the chromosome toward the spindle pole.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference75 articles.

1. Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

2. Localization of Core Spindle Pole Body (SPB) Components during SPB Duplication in Saccharomyces cerevisiae

3. Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore

4. The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling

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