Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments

Author:

Raghunathan Suchitha12,Chimthanawala Afroze13,Krishna Sandeep14,Vecchiarelli Anthony G.5,Badrinarayanan Anjana1

Affiliation:

1. National Centre for Biological Sciences, Tata Institute of Fundamental Research and

2. The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bangalore 560064, India

3. SASTRA University, Thanjavur, Tamil Nadu 613401, India

4. Simons Centre for the Study of Living Machines, Bangalore 560065, India

5. Molecular, Cellular, and Developmental Biology Department, Biological Sciences Building, University of Michigan, Ann Arbor, Michigan 48109

Abstract

The DNA damage response and cell division checkpoints have been well studied in several bacterial model systems, but how cells exit such a checkpoint to restart wild-type growth is unclear. This study highlights a central function for asymmetric division in mediating cellular recovery from DNA damage.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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