Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells-Reference-Cited by-同舟云学术

Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells

Published:2022-11-01 Issue:13 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Stenvall Carl-Gustaf A.¹,Nyström Joel H.¹,Butler-Hallissey Ciarán¹²³,Jansson Theresia¹,Heikkilä Taina R. H.¹,Adam Stephen A.⁴,Foisner Roland⁵,Goldman Robert D.⁴,Ridge Karen M.⁴⁶,Toivola Diana M.¹⁷⁸

Affiliation:

1. Cell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University

2. Turku Bioscience Centre, University of Turku, and Åbo Akademi University, and

3. Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, 13005 Marseille, France

4. Department of Cell and Developmental Biology and

5. Max Perutz Labs, Medical University of Vienna, Vienna Biocenter Campus, 1030 Vienna, Austria

6. Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611

7. InFLAMES Research Flagship Center, Åbo Akademi University, 20500 Turku, Finland

8. Turku Center for Disease Modeling, University of Turku, 20520 Turku, Finland

Abstract

Cytoplasmic keratins couple with SUN2 and lamin A at the nuclear envelope and maintain plectin, LINC complex, lamin and lamin-associated protein levels in colonic epithelial cells. Loss of keratin 8 has no major impact on nuclear shape and size, but compromises nuclear envelope integrity basally and during shear stress.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference70 articles.

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4. Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon

5. The Amount of Keratins Matters for Stress Protection of the Colonic Epithelium

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