PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation-Reference-Cited by-同舟云学术

PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation

Published:2020-09-15 Issue:20 Volume:31 Page:2269-2282
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Foltz Lauren¹,Palacios-Moreno Juan²,Mayfield Makenzie¹,Kinch Shelby¹,Dillon Jordan¹,Syrenne Jed¹,Levy Tyler³,Grimes Mark¹

Affiliation:

1. Division of Biological Sciences, Center for Biomolecular Structure and Dynamics, and Center for Structural and Functional Neuroscience, University of Montana, Missoula, MT 59812

2. University of Minnesota Medical School, Duluth, MN 55812

3. Cell Signaling Technology, Danvers, MA 01923

Abstract

Different receptor tyrosine kinases employ shared downstream cell signaling pathways to induce differentiation or proliferation. The scaffold protein, PAG1 controls SRC-family kinase (SFK) activity in lipid rafts, and new data show that PAG1 also influences SFK sequestration in multivesicular bodies and is required for neuronal differentiation.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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