Unconventional endocytosis and trafficking of transferrin receptor induced by iron-Reference-Cited by-同舟云学术

Unconventional endocytosis and trafficking of transferrin receptor induced by iron

Published:2021-01-15 Issue:2 Volume:32 Page:98-108
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Gammella Elena¹,Lomoriello Irene Schiano²,Conte Alexia²,Freddi Stefano²,Alberghini Alessandra¹,Poli Maura³,Sigismund Sara²⁴,Cairo Gaetano¹,Recalcati Stefania¹

Affiliation:

1. Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy

2. IEO, Istituto Europeo di Oncologia IRCCS, 20141 Milan, Italy

3. Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy

4. Department of Oncology and Hematology-Oncology, Università degli Studi di Milano, 20122, Milan, Italy

Abstract

An unconventional endocytic regulatory process that directs TfR1 to lysosomal degradation in response to iron is reported. This mechanism may represent a novel posttranslational control to prevent iron overload.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference44 articles.

1. Transferrin receptor 1

2. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation

3. Roles of AP-2 in Clathrin-Mediated Endocytosis

4. Recombinant human transferrin: Beyond iron binding and transport

5. Non-transferrin bound iron: A key role in iron overload and iron toxicity

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling;Antioxidants & Redox Signaling;2024-07-30

2. Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes;ACS Nano;2024-02-28

3. Selective cytotoxic effects of nitrogen-doped graphene coated mixed iron oxide nanoparticles on HepG2 as a new potential therapeutic approach;Discover Nano;2024-02-22

4. Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome;Nature Communications;2024-02-03

5. Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells via Hypoxia-Inducible Factor-1α/Transferrin Receptor 1 Signaling Pathway;Antioxidants & Redox Signaling;2024-01-18