Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast-Reference-Cited by-同舟云学术

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast

Published:2021-10-01 Issue:20 Volume:32 Page:ar14
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Pino Marbelys Rodriguez¹²,Nuñez Illyce¹,Chen Chuan¹,Das Maitreyi E.¹³,Wiley David J.¹,D’Urso Gennaro¹,Buchwald Peter¹,Vavylonis Dimitrios⁴,Verde Fulvia¹

Affiliation:

1. Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-1015

2. Department of Biology, Health & Wellness, Miami Dade College, Miami, FL 33176

3. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996

4. Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA, 18015

Abstract

The highly conserved small GTPase Cdc42 regulates polarized cell growth and morphogenesis from yeast to humans. Using both genetic and computational approaches, our findings define a novel role for Cdc42 GAP proteins in determining the morphological fate of cell progeny and ensuring consistent Cdc42 activation and growth patterns across generations.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference56 articles.

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4. Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking

5. Regulation of Fission Yeast Morphogenesis by PP2A Activator pta2

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