DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy-Reference-Cited by-同舟云学术

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

Published:2021-04-01 Issue:7 Volume:32 Page:538-553
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

He Lihua¹,Kennedy Andrew S.¹,Houck Scott¹,Aleksandrov Andrei¹,Quinney Nancy L.¹,Cyr-Scully Alexandra¹,Cholon Deborah M.¹,Gentzsch Martina¹,Randell Scott H.¹,Ren Hong Yu¹,Cyr Douglas M.¹

Affiliation:

1. Department of Cell Biology and Physiology and the Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Abstract

Transmembrane Hsp40s and cytosolic Hsp70 cooperate on the endoplasmic reticulum’s (ER) cytoplasmic face to facilitate the triage of nascent polytopic membrane proteins. DNAJB12 is reported to operate in biosynthetically active ER microdomains to mediate degradation of ER-associated degradation-resistant membrane protein intermediates by selective ER-associated autophagy.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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