Yeast Rgd3 is a phospho-regulated F-BAR–containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology-Reference-Cited by-同舟云学术

Yeast Rgd3 is a phospho-regulated F-BAR–containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology

Published:2020-11-01 Issue:23 Volume:31 Page:2570-2582
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Gingras Robert M.¹,Lwin Kyaw Myo¹,Miller Abigail M.¹,Bretscher Anthony¹

Affiliation:

1. Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853

Abstract

RGD3 ( YHR182w) is a novel RhoGAP in budding yeast whose overexpression suppresses the temperature sensitivity of myo2 smy1 mutants defective in secretory vesicle transport. We show that Rgd3 localizes to polarized vesicles distinct from constitutive secretory vesicles and contributes to cell polarity through its GAP activity on Rho3.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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