The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis-Reference-Cited by-同舟云学术

The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis

Published:2020-09-15 Issue:20 Volume:31 Page:2249-2258
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Dowdell Alexander S.¹,Cartwright Ian M.¹,Goldberg Matthew S.¹,Kostelecky Rachael¹,Ross Tyler¹,Welch Nichole¹,Glover Louis E.¹²,Colgan Sean P.¹

Affiliation:

1. Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO 80045

2. School of Biochemistry and Immunology, Trinity College Dublin, Ireland

Abstract

The transcription factor hypoxia-inducible factor (HIF) mediates adaptation to hypoxia. We found that HIF regulates the autophagy protein ATG9A in intestinal epithelial cells. Subsequent knockdown of ATG9A resulted in tight junction mislocalization and cytoskeletal defects. These results suggest a link among the hypoxia response, autophagy, and junctional biogenesis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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