SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation-Reference-Cited by-同舟云学术

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

Published:2020-11-15 Issue:24 Volume:31 Page:2687-2702
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Le Linh¹²³,Escobar Iliana E.⁴,Ho Tina¹²³,Lefkovith Ariel J.¹²³,Latteri Emily¹²,Haltaufderhyde Kirk D.⁴,Dennis Megan K.¹²⁵,Plowright Lynn⁶,Sviderskaya Elena V.⁶,Bennett Dorothy C.⁶,Oancea Elena⁴,Marks Michael S.¹²

Affiliation:

1. Department of Pathology & Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104

2. Department of Pathology and Laboratory Medicine and Department of Physiology and

3. Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

4. Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912

5. Biology Department, Marist College, Poughkeepsie, NY 12601

6. Molecular & Clinical Sciences Research Institute, St George’s, University of London, London SW17 0RE, UK

Abstract

SLC45A2 encodes a putative transporter in pigment cells and is mutated in oculocutaneous albinism (OCA) type 4. We show that SLC45A2 on mature melanosomes supports melanin synthesis by maintaining lumenal neutralization-initially orchestrated by transient OCA2 activity-and that a common variant imparts reduced activity due to protein instability.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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