C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src

Abstract

The tricellular junction (TCJ) forms at the convergence of three neighboring epithelia. The targeting of Gliotactin, an essential TCJ protein, to the TCJ is controlled by phosphorylation and endocytosis. C-terminal Src kinase controls endocytosis of Gliotactin in an Src-independent manner.