Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells-Reference-Cited by-同舟云学术

Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells

Published:2018-02 Issue:3 Volume:29 Page:356-362
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Xie Xinming¹,Li Shaojun¹,Zhu Yanting¹,Liu Lu¹,Ke Rui¹,Wang Jian¹,Yan Xin¹,Yang Lan¹,Gao Li²,Zang Weijin³,Li Manxiang¹

Affiliation:

1. Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

2. Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224

3. Department of Pharmacology, School of Basic Medical Sciences, Xian Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China

Abstract

Leptin signaling has been found to play an important role in the development of pulmonary hypertension. It was demonstrated that leptin dose- and time-dependently resulted in PPARγ reduction in pulmonary artery smooth muscle cells (PASMC). The study indicates that the ERK1/2 signaling pathway partially mediates leptin-induced PPARγ reduction and PASMC proliferation through up-regulation of Egr-1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference58 articles.

1. Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth

2. Interaction with MEK Causes Nuclear Export and Downregulation of Peroxisome Proliferator-Activated Receptor γ

3. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

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