COMPARISON OF ESTIMATED GLOMERULAR FILTRATION RATE USING DIFFERENT FORMULAS IN TURKISH POPULATION

Abstract

Objective: Creatinine-based equations are generally used in clinical practice to estimate glomerular filtration rates (GFR), but values are not usually consistent. This study aimed to evaluate the difference between estimated GFR values using different equations. Material and Method: Adult Turkish patients with serum creatinine measurements between January to December 2021 and complete demographic data were included. GFR values were calculated using 5 different formulas. GFR calculated with Cockcroft-Gault were normalized to body surface area and added to the comparison. Difference between GFR values and KDIGO stages were evaluated. Albunin/creatinine ratio (ACR) of patients was also assessed. Result and Discussion: A total of 305 patients with average age of 52.92 years were included. Six different GFR calculations were recorded with median values between 51.70 to 71.77 ml/min/1.73m2. Formula of The Modification of Diet in Renal Disease with the race factor for Turkish population resulted in the lowest eGFR values. The ACR values of only 42 patients were available and it was negatively correlated to all GFR values and positively correlated to all KDIGO stages (p<0.05). There were noteworthy variations in GFR values, based on patient demographics and/or equations. The need for novel practical methods for estimating GFR in general and specific patient populations are necessary.