Affiliation:
1. ANKARA ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ, FARMASÖTİK TOKSİKOLOJİ (DR) (ECZACILIK)
2. ANKARA ÜNİVERSİTESİ
3. LOKMAN HEKİM ÜNİVERSİTESİ
Abstract
Objective: This study aimed to determine the DNA damage induced by Bisphenol A (BPA) and Bisphenol S (BPS) on MCF7 cell line.
Material and Method: DNA damage was determined by COMET assay in MCF7 cell line at 0.1, 0.5, 1, 5, 10 and 50 μM concentrations of BPA and BPS.
Result and Discussion: All BPA and BPS concentrations studied (0.1, 0.5, 1, 5, 10 and 50 μM) significantly induced DNA damage on MCF7 cell line compared with control (p<0.05). BPS significantly induced DNA damage more than BPA at the 3 highest concentrations studied (5, 10 and 50 μM) (p<0.05). This study shows that bisphenol derivatives can also cause DNA damage like BPA.
Funder
Ankara University Scientific Research Projects Coordination Unit
Publisher
Ankara Universitesi Eczacilik Fakultesi Dergisi
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