YANIK TEDAVİSİNDE KULLANILMAK ÜZERE LİDOKAİN İÇEREN ALOE VERA JEL FORMÜLASYONUNUN HAZIRLANMASI VE İN VİTRO KARAKTERİZASYONU

Abstract

Objective: In this study, topically applied in situ gel formulations were aimed to design for the modulation of burns, with the active ingredient lidocaine and the gel gained from the Aloe vera plant. The prepared in situ gels were in the liquid form at the room temperature and gelled at the body temperature and adhered to the wound surface, resulting in higher drug residence time. By improving the characteristic properties of the in situ gels, it is aimed to improve patient compliance by obtaining higher local lidocaine concentration. Material and Method: In situ gel formulations separated by giving different gel codes were examined with characteristic analyses. Within the scope of these examinations, measurement of gelation temperature, pH measurement, in vitro lidocaine release, viscosity and rheological properties and the texture profile of the formulations were determined. Result and Discussion: Poloxamer 407 based in situ gels designed for topical treatment containing Aloe vera gel and lidocaine have been shown to increase skin residence time. Among the formulations prepared with different content ratios of the polymers Poloxamer 407, Poloxamer 188, HPMC and CMC, the gels coded F5 and A21 showed acceptable gelation temperature for topical use and sustained lidocaine release for 24 hours. According to these findings, it can be revealed that Poloxamer 407-HPMC based in situ gel formulation may be an effective alternative for topical burn treatment.