ANTIOXIDANT, ENZYME INHIBITORY, AND CYTOTOXIC ACTIVITY SCREENING OF MYRTUS COMMUNIS L.
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Published:2023-07-24
Issue:3
Volume:47
Page:12-12
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ISSN:1015-3918
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Container-title:Ankara Universitesi Eczacilik Fakultesi Dergisi
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language:en
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Short-container-title:Ankara Ecz. Fak. Derg.
Author:
KÖNGÜL ŞAFAK Esra1ORCID, İLGÜN Selen2ORCID, ÇOBAN Kübra Nur1ORCID, AKÇAKAYA MUTLU Sena3ORCID, YILMAZ Halil4ORCID, ŞEKER KARATOPRAK Gökçe3ORCID
Affiliation:
1. ERCIYES UNIVERSITY 2. ERCİYES ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ 3. ERCİYES ÜNİVERSİTESİ 4. ORDU ÜNİVERSİTESİ
Abstract
Objective: The present study aimed to evaluate the biological activities of Myrtus communis L., which has traditional medicinal use for different purposes, from a broad perspective.
Material and Method: The antioxidant (DPPH, ABTS, total phenol, and flavonoid amounts) anti-inflammatory (LOX enzyme inhibition), antidiabetic (α-glucosidase enzyme inhibition), and cytotoxic properties (MTT assay) of a 70% methanol extract made from leaves and dichloromethane, butanol, ethyl acetate, and the residual water fractions were investigated.
Result and Discussion: The DPPH radical scavenging effect of the ethyl acetate fraction, with the highest total phenol and flavonoid content, was found to be 1.4 µg/ml, and the ABTS radical scavenging effect was 2.58 mmol/Trolox. The most potent inhibitor of LOX (IC50: 31.17 µg/ml) and α-glucosidase (96% inhibition at 0.5 mg/ml) enzymes was determined as ethyl acetate extract. Dichloromethane fraction was shown to have the most cytotoxic activity in both Hela and Colo cell lines. This research has given us a better understanding of the traditional use of the M. communis plant, which stands out for its therapeutic properties.
Publisher
Ankara Universitesi Eczacilik Fakultesi Dergisi
Subject
Pharmaceutical Science,Pharmacology
Reference28 articles.
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